• The XCI status of different hESCs was previously

  2018-10-22

  

  The XCI status of different hESCs was previously analyzed mainly by XIST order Z-VEID-FMK and was not conclusive (Hoffman et al., 2005; Adewumi et al., 2007; Shen et al., 2008; Silva et al., 2008; Dvash and Fan, 2009; Dvash et al., 2010). We now propose to characterize the status of X inactivation

• OCN is a marker of late stage osteogenic differentiation

  2018-10-22

  

  OCN is a marker of late stage osteogenic differentiation and regulates matrix mineralization during bone formation. VitD3 had the greatest positive effect on this transcript while Dex had the greatest negative effect. This effect has previously been documented for VitD3 supplemented osteoblast cultu

• The interaction between intact AM and limbal explants does n

  2018-10-22

  

  The interaction between intact AM and limbal explants does not only degrade the matrix of the AM but also activate intracellular signaling cascades triggered by matrix components. By use of selective pharmacological inhibitors, we investigated the downstream effectors critical for intact AM-induced

• To meet this current need our

  2018-10-22

  

  To meet this current need, our goal was to develop a tool that would make automated cell segmentation feasible and efficient in analyzing data from higher organisms, as has been applied to less complex data from lower organisms, such as in bacteria (Locke and Elowitz, 2009). The objective was to ass

• The association between a rather

  2018-10-22

  

  The association between a rather small change in methylation and an important transcriptional switch merits more detailed explanation. First, the bead array assay used to assess 5mC cannot distinguish between 5mC and 5hmC, and in some cases such as the P1 promoter, both DNA marks may display opposit

• There are still some concerns in the

  2018-10-22

  

  There are still some concerns in the studies using human iPSC-based disease models, one of which is that patient-specific iPSC-based models of long-QT syndrome demonstrate relatively prolonged action potentials (Itzhaki et al., 2011) relative to the patients\' QT intervals. Thus, the iPSC-derived CM

• Interestingly our data showed that

  2018-10-22

  

  Interestingly, our data showed that when eLSKSLAM were co-cultured with individual ploidy MM, the significant increase in proliferation was no longer observed. In addition, we observed less than expected proliferation when eLSKSLAM OTX-015 cost were co-cultured with MM that had been stained with Ho

• Initially it was postulated that a

  2018-10-20

  

  Initially it was postulated that a functional FA pathway is a prerequisite for isradipine manufacturer to be reprogrammed to the pluripotent stage as reprogramming could only be achieved in FA patient cells after correction of the FA defect (Raya et al., 2009). More recently however, several groups

• To investigate apoptotic and necrotic cell death we have

  2018-10-20

  

  To investigate apoptotic and necrotic cell death, we have used a phosphatidylserine-binding protein (Annexin-V-FITC) to detect apoptosis-dependent redistribution of phospholipid. Cells were also counter-stained with PI to distinguish apoptosis from necrosis. We found few apoptotic and necrotic kappa

• br Materials methods The derivation and culturing conditions

  2018-10-20

  

  Materials & methods The derivation and culturing conditions of hAT-MSCs are thoroughly described in Supplementary Materials and methods section, while details regarding hiPS lines generation and validation are described elsewhere (Kyrkou et al., in press). Results Discussion Human AT-MSCs

• The original XO karyotype Fig of the donor CVCs

  2018-10-20

  

  The original 45 XO karyotype (Fig. 1) of the donor CVCs was maintained in TS ViPSCs even after prolonged maintenance (passage 25) indicating that the process of reprogramming with episomal vectors and in vitro culture conditions did not alter this iPSC line chromosomally. The iPSC line established i

• In summary our findings demonstrate a functional requirement

  2018-10-20

  

  In summary, our findings demonstrate a functional requirement for FOXO3 as a regulator of Notch signaling in the self-renewal of SCs during muscle regeneration. These findings add to the growing list of cellular mechanisms that have been studied in the context of the proliferation and differentiatio

• Our work implicates exosomes and the miRNAs they

  2018-10-20

  

  Our work implicates exosomes, and the miRNAs they contain, as crucial mediators of CDC-induced cardiac regeneration. CDCs exert diverse but coordinated effects: they recruit endogenous progenitor rxr receptor and coax surviving heart cells to proliferate (Chimenti et al., 2010; Li et al., 2010; Mall

• Prolonged APs and EADs are typical of pharmacologically indu

  2018-10-20

  

  Prolonged APs and EADs are typical of pharmacologically induced LQTS modeled in nonhuman hearts (Shimizu and Antzelevitch, 2000; Studenik et al., 2001; Terentyev et al., 2014), yet few such studies examined [Ca2+]i transients. The lengthening of APs and [Ca2+]i transients after pharmacologically blo

• Altogether this study shows as proof of

  2018-10-20

  

  Altogether, this study shows as proof of principle that conversion of fibroblasts toward a neural cell fate can be achieved solely by small molecule treatment. We identified CB as potent compound to induce neural cell identity and developed a CB-based approach to efficiently generate Schwann ursolic

15270 records 1017/1018 page Previous Next First page 上5页 101610171018