• Here we provide the first definitive evidence that

  2018-10-24

  

  Here we provide the first definitive evidence that an alternative airway progenitor cell, marked by expression of SOX2, is the predominant cell of origin for nascent KRT5+ trpv1 antagonist after influenza infection. This was true for nascent KRT5+ cells that emerge in the airways and those that app

• The correct deposition of m C into RNAs is essential

  2018-10-24

  

  The correct deposition of m5C into RNAs is essential for normal development. Loss-of-function mutations in the NSUN2 gene in both mouse and human cause growth retardation and neurodevelopmental deficits including microcephaly, as well as defects in cognition and motor function (Blanco and Frye, 2014

• There is widespread recognition of the complementary value o

  2018-10-24

  

  There is widespread recognition of the complementary value of hiPSCs in disease modeling. Indeed, a number of studies have revealed mutant HTT-related molecular and cellular abnormalities using human pluripotent stem cells and differentiated cells, e.g., alterations in transcriptomes, proteomes, ATM

• Yet at the same time the extent of human variability

  2018-10-24

  

  Yet at the same time the extent of human variability, of which we are only beginning to take the full measure, poses an important practical problem for the field of iPSC-based modeling. Given background genetic differences between individuals, the key question is which experimental designs and degre

• In this contribution we consider the geometric modeling

  2018-10-24

  

  In this contribution we consider the geometric modeling of middle-size fullerenes growth beginning with C32; namely C34, C36, C38, C40, C42, C44, C46, C48, C50, C52, C54, C56, C58, and C60. We have studied their growth at first obtaining their graphs, what is simpler, and then designing their struct

• br Reduction of the patient

  2018-10-24

  

  Reduction of the patient\'s radiation load The main reason why background radiation appears in the radiation room during proton therapy of the eye is that the majority of the protons are absorbed by the system generating the treatment beam, by the equipment and by the walls of the radiation room.

• br Introduction The pattern of maternal alcohol

  2018-10-24

  

  Introduction The pattern of maternal alcohol consumption over the reproductive life course is greatly understudied. Research involving women׳s use of alcohol has tended to focus on short periods of their lives, generally during pregnancy (Anderson et al., 2013; Maloney et al., 2011; Liu, Mumford

• br Acknowledgements This work was

  2018-10-24

  

  Acknowledgements This work was supported by NIH grants 1R01MD006064 and 1R21HD066312 (Dr. Osypuk, PI), and the Minnesota Population Center grant P2C HD041023. Funders did not have any role in design or conduct of the study; collection, management, analysis, and interpretation of the data; or prep

• Most existing work including studies

  2018-10-24

  

  Most existing work, including studies by Sayed and Zhang, used some variation of degree centrality to evaluate network-based interventions. As Valente (2010) points out, a major limitation of in-degree centrality is that nominations received may be redundant. Borgatti (2006) showed that conventional

• br Theoretical foundation of the study br Methodology A Web

  2018-10-24

  

  Theoretical foundation of the study Methodology A Web-based survey was distributed to 3060 international and/or general manager in charge of the firm\'s foreign business activity of Spanish exporting firms in the food sector, beverage sector, consumer goods, raw materials, industrial products

• Dinardo et al applied nonparametric methods to measure

  2018-10-23

  

  Dinardo et al. (1996) applied nonparametric methods to measure the effects of institutions and labor market factors on the changes of income distribution in the U.S. in the period 1979–1988. They concluded that labor unions and supply/demand shocks are vital to explain the income inequality rise in

• mostly From economical viewpoint taking f as

  2018-10-23

  

  From economical viewpoint, taking f as a production cost, as a production supply and as a vector price. Here, conjugate function f* represent maximum profile in the production. Unfortunately, these economical interpretations hold when f is convex and lower semi continuous, because defined by is

• In the current issue of

  2018-10-23

  

  In the current issue of E-BioMedicine, report intriguing data to show that very young asymptomatic SCA infants, whilst still producing very high total levels of HbF, demonstrate significant alterations in reticulocyte membrane protein expression, in association with reticulocytosis. The infants wit

• SBI-0206965 Vaccine recommendation behaviors were self repor

  2018-10-23

  

  Vaccine recommendation behaviors were self-reported, which is a limitation of our study: declaration or desirability biases cannot be excluded. However, questionnaire data appears to overestimate SBI-0206965 rates by less than 10% (Brien et al., 2012), and self-reported pandemic or seasonal influen

• UNC 0642 Our recent study comparing clinical parameters

  2018-10-23

  

  Our recent study comparing clinical parameters and K+ transport in red UNC 0642 from HbSS and HbSC patients indicated significant differences between the two genotypes (Rees et al., 2015). In particular, KCC activity was higher in HbSC patients with more severe forms of SCD (Rees et al., 2015), whi

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