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br Acknowledgements This work was supported by
2020-02-14
Acknowledgements This work was supported by grants from Agence Nationale de la Recherche (ANR CAPHE) and from Ligue contre le Cancer. We acknowledge the continuous support of CNRS and the University of Strasbourg. We thank the technical assistance of the “Plateforme de Chimie Intégrative de Stras
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br Acknowledgements This work was supported by
2020-02-14
Acknowledgements This work was supported by grants from Agence Nationale de la Recherche (ANR CAPHE) and from Ligue contre le Cancer. We acknowledge the continuous support of CNRS and the University of Strasbourg. We thank the technical assistance of the “Plateforme de Chimie Intégrative de Stras
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Another significant finding in our study was the demonstrati
2020-02-13
Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in CP 154526 (Fig. 11). Because of the consistent protection conferred by CK2 inhibition during OGD, imp
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br Discussion The use of carp primary cell cultures
2020-02-13
Discussion The use of carp primary cell cultures proved to be a valuable approach to evaluate the piscine immune response. A. hydrophila was a more potent stimulator of NO formation by carp leukocytes compared to commercial LPS often used for leukocyte stimulation (Mustafa and Olson, 1998, Chao e
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The involvement of FOXO and
2020-02-13
The involvement of FOXO3 and STAT5 in DNA-PKcs and glutathione reductase IV has not been reported before, and the search by the ECR browser (http://ecrbrowser.decode.org) revealed that 1kb of the 5′ promoter of DNA-PKcs possesses 4 STAT (−908bp to −901bp, −676bp to −656bp, −533bp to −526bp and −66bp
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DDR distribution in healthy fibrotic
2020-02-13
DDR1 distribution in healthy, fibrotic and inflamed tissues Whereas we can easily mine publicly available databases to infer DDR1 expression profile in different tissues (as reported in Fig. 1), fine comprehension of DDR1 biology has been hampered by the absence of a commercially available specific
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br Endothelial mechanotransduction br Apoptosis br Death ass
2020-02-13
Endothelial mechanotransduction Apoptosis Death associated protein kinase Conclusion DAPK is localized to the Bay 11-7821 network, and promotes actomyosin contractility. DAPK stabilizes stress fibers by phosphorylation of MLC (Bialik et al., 2004, Kuo et al., 2003). In endothelial cells
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To ascertain that the slower migrating bands represented pho
2020-02-13
To ascertain that the slower migrating bands represented phosphorylated CDK5, we performed a phosphatase assay. Lysates of Tadalafil synthesis co-expressing p35 and either WT or D144N CDK5 were immunoprecipitated using an anti-p35 antibody. The immunoprecipitates were then dephosphorylated using SA
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Nile tilapia Oreochromis niloticus is an important species f
2020-02-13
Nile tilapia (Oreochromis niloticus) is an important species farmed worldwide (Doan et al., 2018). Lipid-rich diets are commonly used in Nile tilapia aquaculture to reduce feed cost, but impair lipid homeostasis (Huang et al., 2016). Therefore, it is important to determine whether forskolin can stim
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AP 24534 br Methodology The following subsections describe
2020-02-13
Methodology The following subsections describe the steps of the Systematic Literature Review (SLR) process we followed [9]. Results In our review of the literature, we used the definitions provided by the IEEE Standard Computer Dictionary [15] to categorize the claims about the effectiveness
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The estrogenic activity of steroids with a C methyl
2020-02-13
The estrogenic activity of steroids with a C19 methyl group may provide a selective advantage in estrogen physiology that is not provided by E2. In this regard, 5α-androstanediol has been proposed to be a second physiological estrogen in fetal mouse filgotinib based on the timing of ERβ synthesis i
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br Experiments br Numerical simulations br Discussion br Con
2020-02-13
Experiments Numerical simulations Discussion Conclusions By large-caliber PELE with various d/D against RHA plate at low velocity of 415 m s−1, impact experiments against 30 mm RHA target were carried out. Numerical simulations were also conducted to monitor progress of PELE expansion an
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The ERR gene lacks the typical TATA
2020-02-13
The ERRα gene lacks the typical TATA and CAAT boxes, but has multiple consensus Sp1 binding elements in the GC-rich promoter (Shi et al., 1997). Previously, our laboratory has shown that ERRα expression is upregulated in the mouse uterus by estrogen (Shigeta et al., 1997) and recently we identified
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Interestingly anti inflammatory actions for sPLA V
2020-02-13
Interestingly, anti-inflammatory actions for sPLA2-V were also described in mice a few years ago in a model of autoimmune complex mediated arthritis [148]. A novel mechanism was delineated, whereby sPLA2-V promotes phagocytosis of immune complexes by macrophages to ameliorate inflammation in autoimm
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Despite robust translation of GA only small
2020-02-13
Despite robust translation of GA, only small amounts of GR and GP were translated in cultured AG-221 and chick embryo spinal cord neural cells from the 75 copies of G4C2 in monocistronic constructs. Interestingly, GA is also the most common dipeptide found in autopsy tissue in FALS patients with C9
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