• Prolonged APs and EADs are typical of pharmacologically indu

  2018-10-20

  

  Prolonged APs and EADs are typical of pharmacologically induced LQTS modeled in nonhuman hearts (Shimizu and Antzelevitch, 2000; Studenik et al., 2001; Terentyev et al., 2014), yet few such studies examined [Ca2+]i transients. The lengthening of APs and [Ca2+]i transients after pharmacologically blo

• Altogether this study shows as proof of

  2018-10-20

  

  Altogether, this study shows as proof of principle that conversion of fibroblasts toward a neural cell fate can be achieved solely by small molecule treatment. We identified CB as potent compound to induce neural cell identity and developed a CB-based approach to efficiently generate Schwann ursolic

• br Results br Discussion The characterization of

  2018-10-20

  

  Results Discussion The characterization of ISC populations by histological and bulk molecular profiling approaches has resulted in a number of seemingly contradictory findings in the published literature. Specifically, indispensable reserve ISCs marked by Bmi1- and Hopx-CreERT2 candesartan cil

• matrix metalloproteinases br Experimental Procedures br Auth

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Recently, substantial progress has been made to elicit organogenesis in 3D culture (Antonica et al., 2012; Huch et al., 2013; Liu et al., 2010; Sato et al., 2009; Spence et al., 2011). In the neural lineage, embryo

• In this work we have shown the

  2018-10-20

  

  In this work, we have shown the dramatic effect of the loss of FMRP on the gene expression profile of neurons. In the absence of FMRP, the neural hsa-mir-382 levels are decreased, preventing the differentiation-dependent downregulation of REST. The resulting higher levels of REST in FXS-derived neur

• In this work we have shown the

  2018-10-20

  

  In this work, we have shown the dramatic effect of the loss of FMRP on the gene expression profile of neurons. In the absence of FMRP, the neural hsa-mir-382 levels are decreased, preventing the differentiation-dependent downregulation of REST. The resulting higher levels of REST in FXS-derived neur

• br Experimental Procedures br Author Contributions

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments The authors thank Sarah Chan and Jonathan Scolnick for technical assistance with deep sequencing and Yusuf Ali, Hiram Chipperfield, Rory Johnson, and Pauline Tay for their early work on the pancreatic differentiation protocol and

• br Results br Discussion AXL is a member of the

  2018-10-20

  

  Results Discussion AXL is a member of the TAM (TYRO3-, AXL-, MER-TK) subfamily of RTKs (O’Bryan et al., 1991). This family shares structural homology, including a conserved sequence within the kinase domain (Linger et al., 2008). In contrast to little or no expression in normal order TH-302 ti

• Kearns et al demonstrated that dCas transcriptional

  2018-10-20

  

  Kearns et al. (2014) demonstrated that dCas9 transcriptional activators and repressors can be used to control human pluripotent stem cell differentiation by targeting endogenous SOX17 and OCT4. We have expanded the target gene list to additional key factors in the endodermal and pancreatic different

• The present study showed that transplantation of iBAs and dB

  2018-10-20

  

  The present study showed that transplantation of iBAs and dBAs markedly reduced diet-induced obesity, dyslipidemia, and insulin resistance in mice (Figures 2, 6, and 7). The dBAs controlled insulin resistance in an UCP1-dependent fashion, strongly suggesting the UCP1-mediated energy expenditure as t

• Analysis of TCR signatures predicts

  2018-10-20

  

  Analysis of TCRβ signatures predicts that several initial “founder” clones of iPSC were present at P4 but that these resolved to a single clone by P20. This was somewhat surprising, as it is often assumed that individually picked colonies of iPSC are derived from a single cell and are therefore clon

• br Experimental Procedures br Author Contributions br

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments This work was supported by grants from the Ministerio de Ciencia e Innovación (Grant SAF2012-38914), Plan Nacional de I + D + I, Spain and the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (Grant 2014 SGR229), Depar

• Previous studies have shown that BM

  2018-10-20

  

  Previous studies have shown that BM-MSCs can be labeled by markers including Prx1, Dermo1, leptin receptor, and Nestin (Mendelson and Frenette, 2014; Morrison and Scadden, 2014). Our lineage-tracing experiments confirm that Prx1+ BM-MSCs can differentiate into osteoblasts, chondrocytes, and adipocyt

• Zscan is sometimes considered as a marker of

  2018-10-20

  

  Zscan4 is sometimes considered as a marker of highly pluripotent status, merely due to its expression at the two-cell stage during development (Cerulo et al., 2014). However, based on our observation, we would like to propose that the expression of Zscan4 is activated in response to telomere shorten

• br Results br Discussion The development of miRNA based

  2018-10-20

  

  Results Discussion The development of miRNA-based therapy approaches has become one of the most attractive areas of tissue engineering (Lian et al., 2012). Recently, many studies reported that miRNAs are important regulators for the therapy or differentiation of stem abiraterone acetate (Cho

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