• The original XO karyotype Fig of the donor CVCs

  2018-10-20

  

  The original 45 XO karyotype (Fig. 1) of the donor CVCs was maintained in TS ViPSCs even after prolonged maintenance (passage 25) indicating that the process of reprogramming with episomal vectors and in vitro culture conditions did not alter this iPSC line chromosomally. The iPSC line established i

• In summary our findings demonstrate a functional requirement

  2018-10-20

  

  In summary, our findings demonstrate a functional requirement for FOXO3 as a regulator of Notch signaling in the self-renewal of SCs during muscle regeneration. These findings add to the growing list of cellular mechanisms that have been studied in the context of the proliferation and differentiatio

• Our work implicates exosomes and the miRNAs they

  2018-10-20

  

  Our work implicates exosomes, and the miRNAs they contain, as crucial mediators of CDC-induced cardiac regeneration. CDCs exert diverse but coordinated effects: they recruit endogenous progenitor rxr receptor and coax surviving heart cells to proliferate (Chimenti et al., 2010; Li et al., 2010; Mall

• Prolonged APs and EADs are typical of pharmacologically indu

  2018-10-20

  

  Prolonged APs and EADs are typical of pharmacologically induced LQTS modeled in nonhuman hearts (Shimizu and Antzelevitch, 2000; Studenik et al., 2001; Terentyev et al., 2014), yet few such studies examined [Ca2+]i transients. The lengthening of APs and [Ca2+]i transients after pharmacologically blo

• Altogether this study shows as proof of

  2018-10-20

  

  Altogether, this study shows as proof of principle that conversion of fibroblasts toward a neural cell fate can be achieved solely by small molecule treatment. We identified CB as potent compound to induce neural cell identity and developed a CB-based approach to efficiently generate Schwann ursolic

• br Results br Discussion The characterization of

  2018-10-20

  

  Results Discussion The characterization of ISC populations by histological and bulk molecular profiling approaches has resulted in a number of seemingly contradictory findings in the published literature. Specifically, indispensable reserve ISCs marked by Bmi1- and Hopx-CreERT2 candesartan cil

• matrix metalloproteinases br Experimental Procedures br Auth

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Recently, substantial progress has been made to elicit organogenesis in 3D culture (Antonica et al., 2012; Huch et al., 2013; Liu et al., 2010; Sato et al., 2009; Spence et al., 2011). In the neural lineage, embryo

• In this work we have shown the

  2018-10-20

  

  In this work, we have shown the dramatic effect of the loss of FMRP on the gene expression profile of neurons. In the absence of FMRP, the neural hsa-mir-382 levels are decreased, preventing the differentiation-dependent downregulation of REST. The resulting higher levels of REST in FXS-derived neur

• In this work we have shown the

  2018-10-20

  

  In this work, we have shown the dramatic effect of the loss of FMRP on the gene expression profile of neurons. In the absence of FMRP, the neural hsa-mir-382 levels are decreased, preventing the differentiation-dependent downregulation of REST. The resulting higher levels of REST in FXS-derived neur

• br Experimental Procedures br Author Contributions

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments The authors thank Sarah Chan and Jonathan Scolnick for technical assistance with deep sequencing and Yusuf Ali, Hiram Chipperfield, Rory Johnson, and Pauline Tay for their early work on the pancreatic differentiation protocol and

• br Results br Discussion AXL is a member of the

  2018-10-20

  

  Results Discussion AXL is a member of the TAM (TYRO3-, AXL-, MER-TK) subfamily of RTKs (O’Bryan et al., 1991). This family shares structural homology, including a conserved sequence within the kinase domain (Linger et al., 2008). In contrast to little or no expression in normal order TH-302 ti

• Kearns et al demonstrated that dCas transcriptional

  2018-10-20

  

  Kearns et al. (2014) demonstrated that dCas9 transcriptional activators and repressors can be used to control human pluripotent stem cell differentiation by targeting endogenous SOX17 and OCT4. We have expanded the target gene list to additional key factors in the endodermal and pancreatic different

• The present study showed that transplantation of iBAs and dB

  2018-10-20

  

  The present study showed that transplantation of iBAs and dBAs markedly reduced diet-induced obesity, dyslipidemia, and insulin resistance in mice (Figures 2, 6, and 7). The dBAs controlled insulin resistance in an UCP1-dependent fashion, strongly suggesting the UCP1-mediated energy expenditure as t

• Analysis of TCR signatures predicts

  2018-10-20

  

  Analysis of TCRβ signatures predicts that several initial “founder” clones of iPSC were present at P4 but that these resolved to a single clone by P20. This was somewhat surprising, as it is often assumed that individually picked colonies of iPSC are derived from a single cell and are therefore clon

• br Experimental Procedures br Author Contributions br

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments This work was supported by grants from the Ministerio de Ciencia e Innovación (Grant SAF2012-38914), Plan Nacional de I + D + I, Spain and the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (Grant 2014 SGR229), Depar

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