• br The important role of the Hippo

  2018-11-08

  

  The important role of the Hippo kinase cascade in suppressing cell proliferation led Heallen, Martin, and colleagues to hypothesize that Hippo signaling deficiency would cause cardiac overgrowth. This hypothesis was supported by the cardiac-restricted inactivation of Mst1/2, Sav1, and Lats2, which

• different expression It has recently been shown that

  2018-11-08

  

  It has recently been shown that murine IHBD and EHBD systems develop from distinct stem different expression (Spence et al., 2009). In addition, we have found adult mouse gallbladder stem cells to be unique or distinct compared to IHBD cells (Manohar et al., 2011). We therefore chose to evaluate th

• Mammalian muscle differentiation is governed by the expressi

  2018-11-08

  

  Mammalian muscle differentiation is governed by the expression of a series of master regulatory transcription factors, collectively called myogenic regulatory factors (MRFs) (Bentzinger et al., 2012; Molkentin and Olson, 1996). Proliferating myoblasts start expressing MRFs, i.e. MyoD, myogenin, MRF4

• br Resource details br We generated KCL clinical grade hESC

  2018-11-08

  

  Resource details We generated KCL032 clinical grade hESC line following protocols, established previously (Ilic et al., 2012; Stephenson et al., 2012), and now adapted to cGMP conditions. The expression of the pluripotency markers was tested after freeze/thaw cycle (Fig. 1). Differentiation pot

• In addition to supplying a source of

  2018-11-08

  

  In addition to supplying a source of growth factors and signaling molecules, blood vessels also provide a physical framework that can support the migration of neural progenitors during development and in the adult nobiletin (Whitman et al., 2009). In the embryonic and adult rodent SVZ, newly born p

• Further support for the hierarchical

  2018-11-08

  

  Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r

• The pig has many advantages over mouse

  2018-11-08

  

  The pig has many advantages over mouse models for pre-clinical studies involving hESC-CPC transplantation, namely its similar heart size and physiology to human. In addition, pig cardiomyocytes have been shown to exhibit similar contraction rates and analogous action potential duration to humans (St

• Comparative analysis of transgenic hPAX

  2018-11-08

  

  Comparative analysis of transgenic hPAX6GFP expression revealed similarities between the retinal organoid system and the mouse retina in vivo. Our analyses indicated a similar sequence of hPAX6GFP+ retinal cell types in mice in vivo, and in mESC- and hESC-derived retinal organoids: progenitors and r

• ASXL belongs to the enhancer of trithorax group TrxG

  2018-11-08

  

  ASXL1 belongs to the enhancer of trithorax group (TrxG) and polycomb group (PcG) (ETP), and genetically interacts with CBX2 in mice (Fisher et al., 2010). PcG and trxG proteins are key regulators for the expression of numerous developmental genes by silencing or activating gene expression, respectiv

• This special issue of features

  2018-11-07

  

  This special issue of features selected articles presented at the 7th Sao Paulo School of Economics Conference Series, which subject was Macroeconomics in Emerging Markets. The Conference was held at the Sao Paulo School of Economics of Getulio Vargas Foundation in Sao Paulo, Brazil, on August 3, 20

• caffeic acid phenethyl ester Furthermore an independent asso

  2018-11-07

  

  Furthermore, an independent association between SOS episodes and sleep disturbances such as RBD symptoms was observed. Cumulative evidence shows that RBD precedes the development of PD by many years [24–26]. Previously, a reduction of median cerebellar peduncle that carries key structures from the r

• Sleep disturbances and non restorative

  2018-11-07

  

  Sleep disturbances and non-restorative sleep are frequently occurring in patients with anxiety and depressive disorders (AND) [1,2,5–7]. Compared to healthy subjects, both insomnia (40–90%) and hypersomnia (5–10%) are more common in depression and related affective disorders. Persistent sleep distur

• The most important change brought by the modern

  2018-11-07

  

  The most important change brought by the modern episteme was that “time” took on the privileged position, which was previously ascribed to “space” (table). With this new outlook, which delves vertically and deeply and within things, which led to seeing labour as the foundation of all economic laws,

• The accuracy of the Citizen Scientist classification of

  2018-11-07

  

  The accuracy of the Citizen Scientist classification of T-5224 receptor status was extremely good for the subset of images on which there was agreement between pathologist and Citizen Scientist on the presence of cancer cells. The concordance between the pseudo-Allred score assigned by Citizen Scien

• Particulate matter was characterized in broncho alveolar lav

  2018-11-07

  

  Particulate matter was characterized in broncho-alveolar lavage fluid (BALF) extracts and in situ in AM of asthmatic Parisian children. Asthmatic patients, rather than healthy subjects, were selected for the study since fiber-optic bronchoscopy with broncho-alveolar lavage is routinely performed in

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