• br Resource details br We generated KCL clinical grade hESC

  2018-11-08

  

  Resource details We generated KCL032 clinical grade hESC line following protocols, established previously (Ilic et al., 2012; Stephenson et al., 2012), and now adapted to cGMP conditions. The expression of the pluripotency markers was tested after freeze/thaw cycle (Fig. 1). Differentiation pot

• In addition to supplying a source of

  2018-11-08

  

  In addition to supplying a source of growth factors and signaling molecules, blood vessels also provide a physical framework that can support the migration of neural progenitors during development and in the adult nobiletin (Whitman et al., 2009). In the embryonic and adult rodent SVZ, newly born p

• Further support for the hierarchical

  2018-11-08

  

  Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r

• The pig has many advantages over mouse

  2018-11-08

  

  The pig has many advantages over mouse models for pre-clinical studies involving hESC-CPC transplantation, namely its similar heart size and physiology to human. In addition, pig cardiomyocytes have been shown to exhibit similar contraction rates and analogous action potential duration to humans (St

• Comparative analysis of transgenic hPAX

  2018-11-08

  

  Comparative analysis of transgenic hPAX6GFP expression revealed similarities between the retinal organoid system and the mouse retina in vivo. Our analyses indicated a similar sequence of hPAX6GFP+ retinal cell types in mice in vivo, and in mESC- and hESC-derived retinal organoids: progenitors and r

• ASXL belongs to the enhancer of trithorax group TrxG

  2018-11-08

  

  ASXL1 belongs to the enhancer of trithorax group (TrxG) and polycomb group (PcG) (ETP), and genetically interacts with CBX2 in mice (Fisher et al., 2010). PcG and trxG proteins are key regulators for the expression of numerous developmental genes by silencing or activating gene expression, respectiv

• This special issue of features

  2018-11-07

  

  This special issue of features selected articles presented at the 7th Sao Paulo School of Economics Conference Series, which subject was Macroeconomics in Emerging Markets. The Conference was held at the Sao Paulo School of Economics of Getulio Vargas Foundation in Sao Paulo, Brazil, on August 3, 20

• caffeic acid phenethyl ester Furthermore an independent asso

  2018-11-07

  

  Furthermore, an independent association between SOS episodes and sleep disturbances such as RBD symptoms was observed. Cumulative evidence shows that RBD precedes the development of PD by many years [24–26]. Previously, a reduction of median cerebellar peduncle that carries key structures from the r

• Sleep disturbances and non restorative

  2018-11-07

  

  Sleep disturbances and non-restorative sleep are frequently occurring in patients with anxiety and depressive disorders (AND) [1,2,5–7]. Compared to healthy subjects, both insomnia (40–90%) and hypersomnia (5–10%) are more common in depression and related affective disorders. Persistent sleep distur

• The most important change brought by the modern

  2018-11-07

  

  The most important change brought by the modern episteme was that “time” took on the privileged position, which was previously ascribed to “space” (table). With this new outlook, which delves vertically and deeply and within things, which led to seeing labour as the foundation of all economic laws,

• The accuracy of the Citizen Scientist classification of

  2018-11-07

  

  The accuracy of the Citizen Scientist classification of T-5224 receptor status was extremely good for the subset of images on which there was agreement between pathologist and Citizen Scientist on the presence of cancer cells. The concordance between the pseudo-Allred score assigned by Citizen Scien

• Particulate matter was characterized in broncho alveolar lav

  2018-11-07

  

  Particulate matter was characterized in broncho-alveolar lavage fluid (BALF) extracts and in situ in AM of asthmatic Parisian children. Asthmatic patients, rather than healthy subjects, were selected for the study since fiber-optic bronchoscopy with broncho-alveolar lavage is routinely performed in

• br Materials and Methods br

  2018-11-07

  

  Materials and Methods Results Discussion This variance-component analysis study assessed five genetic and familial environment risk contributions to MDD and SDD using GS:SFHS, a Scottish sample comprising close and distant relatives with genome-wide genotyping data. We showed that the commo

• br Liver Fluke Infections and Cholangiocarcinoma Opisthorchi

  2018-11-07

  

  Liver Fluke Infections and Cholangiocarcinoma Opisthorchiasis and clonorchiasis are caused by fish-borne liver flukes of the trematode family Opisthorchiidae. >45 million people worldwide are infected by these pathogens. Species of opisthorchiid flukes that cause disease in humans are Opisthorchi

• The first SCAPs were identified through expression profiling

  2018-11-07

  

  The first SCAPs were identified through expression profiling of senescent vs. non-senescent human purchase EZ Cap Reagent GG (3\' OMe) and confirmed in RNA interference studies (Zhu et al., 2015b). The pathways included networks related to BCL-2/BCL-XL, PI3K/AKT, p53/p21/serpines, dependence recept

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