• Research in rodents suggests that NPCs

  2018-11-02

  

  Research in rodents suggests that NPCs are interesting candidates for cell-based therapy of various neurodegenerative diseases. For example, transplantation of NPCs can improve cognition in a mouse model of Alzheimer\'s disease (Blurton-Jones et al., 2009), induce remyelination in a mouse model of m

• Ventricular cardiomyocytes VCMs are the most extensively inj

  2018-11-02

  

  Ventricular cardiomyocytes (VCMs) are the most extensively injured cardiac cell type in ischemic heart disease and, as a result, the leading cause of reduced cardiac function. Therefore, it is of great interest to generate a renewable source of VCMs from ESCs for cell-based therapies to treat heart

• pilocarpine hydrochloride The gain of q is

  2018-11-02

  

  The gain of 20q11.21 is not specific to pluripotent pilocarpine hydrochloride and is a common feature of many screened cancer cells and cancer types in which knockdown of BCL2L1 is detrimental to cancer cell proliferation (Beroukhim et al., 2010). It has also been suggested that 20q amplification i

• Since mitochondria are a principal source

  2018-11-02

  

  Since mitochondria are a principal source of ROS production, we also investigated whether PGC-1α-dependent mitochondrial changes result in altered ROS levels in cardiomyocytes. Although PGC-1α can induce the expression of antioxidant enzymes (St-Pierre et al., 2006), in this context the impact of ha

• RPE monolayers grown on cell carriers would facilitate

  2018-11-02

  

  RPE monolayers grown on cell carriers would facilitate surgical handling and long-term functionality by substituting some or all of the functions of the aged Bruch’s membrane (Binder et al., 2007). Coimplantation of differentiated RPE monolayers on a substrate has been attempted in animal models onl

• Potential candidates contributing to the fate determination

  2018-11-02

  

  Potential candidates contributing to the fate determination in the injured spinal cord include bone morphogenetic proteins (BMPs) — in particular BMP2 and BMP4, which strongly promote astroglial differentiation at the expense of oligodendroglial and neuronal differentiation (Bonaguidi et al., 2005;

• br Materials and methods br

  2018-11-02

  

  Materials and methods Author disclosure statement Acknowledgments We thank Muscle Tissue Culture Collection (MTCC) for providing the sample. The Muscle Tissue Culture Collection is part of the German network on muscular dystrophies (MD-NET, service structure S1, 01GM0601) and the German net

• Recently several clinical trials of stem cell

  2018-11-02

  

  Recently, several clinical trials of stem-cell-based therapy for SCI using either human NS/PCs (Cummings et al., 2005; Salazar et al., 2010) or human ESC-derived OPCs (Strauss, 2010) have been initiated. Compared with these stem cells, iPSCs raise fewer ethical concerns in certain countries (Nori et

• cell adhesion molecules We obtained some evidence that NMD n

  2018-11-02

  

  We obtained some evidence that NMD not only influences hESC fate through TGF-β and BMP signaling, but also through the WNT, FGF, and NOTCH pathways (Figure 2E). This raises the possibility that the ability of NMD to influence cell adhesion molecules and mesoderm differentiation is a combinatorial pr

• Using expression data from teratomas

  2018-11-02

  

  Using expression data from teratomas, we were able to identify a large variety of differentiated tissues within them. This allowed us to analyze a repertoire of differentiated cell types in each embryonic germ layer. Teratomas initiated from PSCs express characteristic genes of all analyzed tissues

• The present study repeated the examination of the

  2018-11-02

  

  The present study repeated the examination of the R(λ) spectra of all ion-implanted samples, and of some of the initial samples (reverse non-implanted surfaces of massive p-PbS : O+ crystals were used as initial objects). These examinations allowed to establish that no perceptible changes beyond the

• The DCM assumes that the frequency dependence for the dielec

  2018-11-02

  

  The DCM assumes that the frequency dependence for the dielectric permittivity can be expressed as Expression (6) describes the dielectric function of a single-mode crystal in the phonon frequency range [13]. Here ωLO and ωTO are the frequencies of the longitudinal and the transverse optical phono

• The goal of this contribution is to fill the existing

  2018-11-02

  

  The goal of this contribution is to fill the existing gap in the structural studies. In the first stage, we have focused our attention on examining the features of the temperature evolution of the structure of the high-temperature phase of solid (1–x)Pb(Fe2/3W1/3O3)–(x)PbTiO3 solutions in the MPB re

• br Assuming the curvature of the

  2018-11-02

  

  Assuming the curvature of the beam shape to be constant along the length of the piezoelectric actuator, we can take that where the coefficient =e31(–) is the same for all actuators, is the electrical voltage applied to the ith piezoelectric actuator. Thus, we assume that each actuator is fixed

• Social exposures have complex and dynamic relationships and

  2018-11-02

  

  Social exposures have complex and dynamic relationships and interactions, (Hertzman & Boyce, 2010) but only a few studies examined whether the impact of neighborhood exposures on PTD varies by social factors. Philips et al., found no evidence that the association between neighborhood quality and spo

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