• Molecular docking quantitative structure activity relationsh

  2023-10-09

  

  Molecular docking, quantitative structure–activity relationship (QSAR) and high-throughput virtual screening (HTVS) studies have a very widespread use in computer-assisted drug design.25, 26, 27, 28 Suvannang et al. used the published X-ray crystallographic data to examine known aromatase inhibitors

• ARG I is one of the most important mammalian enzymes

  2023-10-09

  

  ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino Dihydro-β-erythroidine hydrobromide and nucleotide metabolism [18]. ARG I deficiency leads to hyperargininemia, char

• In this study we first determined whether AIF

  2023-10-09

  

  In this study, we first determined whether AIF in bovine LT muscle is expressed and the mitochondria released AIF-mediated apoptosis during postmortem aging. For apoptotic issues, the mitochondrial outer membrane is permeabilized, and AIF translocates to the cytosol and to the nucleus, where it indu

• br Conflicts of interest br Contributors br

  2023-10-09

  

  Conflicts of interest Contributors Introduction Lipid oxidation and enzymatic activities are some of the most significant problems in the food industry. These reactions lead to changes in chemical composition which in turn reduce the quality and shelf life of food products. Most of the anti

• The evaluation of serum electrolytes e g sodium potassium

  2023-10-09

  

  The evaluation of serum electrolytes (e.g.: sodium, potassium, urea, creatinine, and uric acid), liver transaminases, blood counts (e.g. identification of thrombocytopenia, and bilirubin), 24-h urine (in order to monitor proteinuria), and heart rate and lung function of the mother should be performe

• Recent studies revealed that certain plant derived compounds

  2023-10-09

  

  Recent studies revealed that certain plant-derived compounds can also interfere with AR function. One way of such an interference is by modulating its expression levels. This is the case for the two flavonoids quercetin and luteolin that have been reported to repress the function of AR by inhibiting

• br Introduction Nonalcoholic fatty liver disease NAFLD

  2023-10-09

  

  Introduction Nonalcoholic fatty liver disease (NAFLD) is a clinicopathologic spectrum of liver pathologies associated with excessive accumulation of fat in the liver. This spectrum is continuous but can be graded based on pathological features; in increasing severity, these are: bland steatosis,

• br Materials and met http

  2023-10-09

  

  Materials and methods Results The values for body weight are shown in Fig. 1. Body weight was measured every day. The body weight of the young mice in the control (i.e. no-stress) group was not significantly different from that of the young mice in the stress group. However, the middle-aged mi

• br Results br Discussion Many tumor cells rely

  2023-10-09

  

  Results Discussion Many tumor Nitrotetrazolium Blue chloride rely on EAAs to provide fundamental building blocks for macromolecular biosynthesis because they cannot synthesize EAAs de novo (Hattori et al., 2017; Sheen et al., 2011). Therefore, they must use highly effective transporters to max

• br Materials and Methods br Results In

  2023-10-09

  

  Materials and Methods Results In the Base Analysis (53% of patients having access to the ALK test in both Current and Alternative Scenarios), a total of 16,583 patients were tested of whom 1,252 were assumed to be ALK-positive. A more extensive use of Ventana in the Alternative Scenario determ

• HT modulates cortical and hippocampal pyramidal cell functio

  2023-10-08

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal 2143 as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 2015, Da

• br Conflict of interest statement br Benign prostatic hyperp

  2023-10-08

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal ski or skii australia in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 ce

• During the year study period of men

  2023-10-08

  

  During the 4-year study period, 19.9% of men in the dutasteride group developed prostate cancer as compared to 25.1% in the placebo group, which represents an absolute risk ae3 australia of 5.1% for men taking dutasteride (Pe weighed against the prospect of undesirable sexual side effects and decre

• In order to increase the oral bioavailability abiraterone is

  2023-10-08

  

  In order to increase the oral bioavailability, abiraterone (157) is being used in the form of its 3β-acetoxy prodrug, abiraterone acetate (156). In spite of the fact that high-fat meals increase the oral pemetrexed disodium of abiraterone acetate (156), it is recommended that this drug should be ta

• br Perspective AA LA and other PUFAs and their lipid

  2023-10-08

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

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