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The number of times an
2023-11-20
The number of times an animal reared was the only emotional behavior that was significantly higher in the young mice than in the middle-aged group. This may be explained by diminished curiosity or augmented ambulation with aging (Lalonde and Strazielle, 2008). A recent study showed that middle-aged
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In a recent series of studies from
2023-11-20
In a recent series of studies from our laboratory, to characterize the contractile systems within the rat mianserin synthesis wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist i
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The putative physiological meaning of epinephrine related
2023-11-20
The putative physiological meaning of epinephrine-related hepatic drug transporter regulation remains to be established. It is nevertheless noteworthy that the catecholamine rather decreases expression of sinusoidal SLC transporters like NTCP, OAT2, OAT7, OCT1, OATP1B1 and OATP2B1 whereas those of c
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vasopressin receptor PKA signalling in the http www apexbt c
2023-11-20
PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the vasopressin receptor to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucl
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br Acknowledgements This work was supported by grants
2023-11-20
Acknowledgements This work was supported by grants from the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (973) (Grant No.: 2013CB733602), the Major Research Plan of the National Natural Science Foundation of C
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To our knowledge BAY has not progressed to clinical
2023-11-20
To our knowledge, BAY 60-6583 has not progressed to clinical development and remains to be the only ADORA2B agonist that has been developed.33, 34 Further development of similar compounds would be beneficial in future fibrosis research. One of the limitations of our study is being limited to in vit
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br Acknowledgments br Introduction Hypospadias is a common c
2023-11-20
Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,
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br Disclosure statement br Acknowledgements The work was
2023-11-20
Disclosure statement Acknowledgements The work was supported by the National Science Foundation of China (Nos. 81273526, 81473268) and Natural Science Foundation of Colleges and Universities (Nos. KJ2017A197). What is already known What this article adds Introduction Sevoflurane is o
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V ATPase is a complex enzyme that is composed
2023-11-20
V-ATPase is a complex enzyme that is composed of several subunits, which are assembled into two domains: trans-membrane (V0) and cytosolic (V1) domains [3,5]. Epididymal epithelial AGK 2 australia of rats has been reported to contain V-ATPase which is distributed at the apical pole of the narrow an
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Then Autodock was employed for
2023-11-20
Then, Autodock4.2 was employed for site directed docking on AD with the ligands of the cluster(s) having high binding affinities in VS II experiment (Morris et al., 2009). Docking protocols were followed as per our earlier report with 200 GA (genetic algorithm) run (Kalani et al., 2015). Likewise, l
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In recent years the higher
2023-11-20
In recent years, the ‘higher lipophilicity’-thus-‘better performance’ tenet, derived from the polar paradox theory applied to micro-structured media, was challenged by novel and unexpected experimental results. In particular, the synthesis of many complete series of fatty Metabolism Compound Library
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Discussion The present experiments follow up and
2023-11-20
Discussion The present experiments follow-up and are completely consistent with our prior findings [26] that blood Aβ is subject to peripheral clearance by a major pathway for circulating pathogens in primates, immune adherence [30,31]. CR1-mediated erythrocyte immune adherence, as well as CR1-medi
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br Acknowledgements This work was supported by grants
2023-11-18
Acknowledgements This work was supported by grants from the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (973) (Grant No.: 2013CB733602), the Major Research Plan of the National Natural Science Foundation of C
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A highly attenuated B pertussis strain
2023-11-18
A highly attenuated B. pertussis strain, named BPZE1, has recently been described [10]. It produces enzymatically inactive pertussis toxin (PT), no dermonecrotic toxin and only trace amounts of tracheal cytotoxin. Markedly reduced lung pathology was observed in mice intranasally (i.n.) infected with
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br Acknowledgments The authors would
2023-11-18
Acknowledgments The authors would like to thank Ms. Ashley Davis for her administrative assistance in preparing this article and Mr. Dan Beck for his artistic contributions to Fig. 1. Introduction Acetylcholine is the most abundant neurotransmitter in the central nervous system (CNS) of insec
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