• Integrin engagement triggers activation of

  2021-12-09

  

  Integrin engagement triggers activation of several signaling pathway including Fak, which is recognized as the key signal transduction factor in the integrin signaling pathway that functions by activating downstream signaling in focal adhesion plaques. Whether changes in integrin-FAK signaling pathw

• The ETB receptor has been

  2021-12-09

  

  The ETB receptor has been shown to decrease sodium transport in the renal medullary collecting duct and medullary thick ascending limb of Henle10, 11, 12, 13, 18. However, both inhibitory and stimulatory effects of endothelin have been reported in the proximal tubule16, 47, 48, 49. In the rat, endot

• In this study we also investigated the role of GST

  2021-12-08

  

  In this study, we also investigated the role of GST clodronate in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In contrast, a previo

• So far GnRH receptors have been detected

  2021-12-08

  

  So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa pathways cu of pre-ovulatory follicles, but not of follicles from the primordial to

• In the present study recipient oestradiol serum levels

  2021-12-08

  

  In the present study, recipient oestradiol serum levels on the day of donor oocyte retrieval or warming were found to be significantly higher in the antagonist group and higher than 100 pg/ml in all cases. Serum oestradiol level has been reported to have no effect on endometrial receptiveness in ooc

• We next compared the enhancing effects of nM

  2021-12-08

  

  We next compared the enhancing effects of 100nM zinc on currents produced by a low concentration of glycine with zinc effects on the same currents produced by the partial agonist taurine. In this experiment, zinc was co-applied with concentrations of glycine or taurine producing 5–10% of the maximal

• The typical pharmacophore for GPR agonists

  2021-12-08

  

  The typical pharmacophore for GPR40 agonists contains four parts: head (acid moiety), central (phenyl ring), linker and tail (aromatic carbocyclic or heterocyclic ring) [20]. On the other hand, the chemical features that are required for the PPARγ agonists include hydrogen bond donors and acceptors

• Although in in vitro analyses GANT sensitized Daoy cells to

  2021-12-08

  

  Although in in vitro analyses GANT61 sensitized Daoy STO-609 acetate australia to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced

• br Disclosure br Ghrelin System

  2021-12-08

  

  Disclosure Ghrelin System The existence of the ghrelin system has been demonstrated in many species through a variety of biochemical, anatomical, and genetic studies. It is a complex and intricate regulatory system comprised of several peptides, including mature ghrelin and its derivative des-

• The OTR and GHSR are known to play similar roles

  2021-12-08

  

  The OTR and GHSR are known to play similar roles in centrally regulated behaviours, where the OTR is implicated in mood, sociability and appetite regulation (Morton et al., 2012; Myers et al., 2014; Sala et al., 2013; Lukas et al., 2011; Slattery and Neumann, 2010), with the GHSR primarily involved

• As shown in Table the results of individual prediction model

  2021-12-08

  

  As shown in Table 3, the results of individual prediction modeling with chemicals at 0.4 mM, 0.6 mM, and 0.8 mM would lead to lesser sensitivity of 60.0%, 65.0%, and 65.0%, respectively, in microsome-unused group, and 85.0%, 85.0%, and 90.0%, in microsome-used group. If we consider only the results

• Axitinib mg The current gold standard for diagnosing BAM or

  2021-12-08

  

  The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) Axitinib mg (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated taurocholic acid an

• In this study we have investigated the expression

  2021-12-08

  

  In this study, we have investigated the expression of FXR and TGR5 in CCA tissues in two independent cohorts of patients and determined their association with tumor clinicopathological parameters. The expression of both BA receptors was also evaluated in CCA human cells and normal human cholangiocyt

• br Conclusion br Acknowledgements This study was supported b

  2021-12-07

  

  Conclusion Acknowledgements This study was supported by the China Postdoctoral Science Foundation (No.2015M581817), the National Research Council of Science and Technology Support Program (2015BAD03B05-06), and the Priority Academic Program Development of Jiangsu Higher Education Institutions

• Aspartame l aspartyl l phenylalanine methylester is

  2021-12-07

  

  Aspartame (l-aspartyl l-phenylalanine methylester) is a dipeptide artificial sweetener that is widely used as a non-nutritive sweetener in various food products [1]. The increased market of dietary products and the development of new synthetic sweetening compounds have not been sufficiently explored

16033 records 522/1069 page Previous Next First page 上5页 521522523524525 下5页 Last page