• Semantics play an important role in

  2021-05-20

  

  Semantics play an important role in software component-based development as they improve components identification, selection and integration through, among others, the use of ontologies (Kaur and Mishra, 2017). Analogously, they allow to improve discovery, composition and reuse in the context of We

• Almost all previously published haplotype association studie

  2021-05-20

  

  Almost all previously published haplotype association studies have demonstrated the importance of haplotype reconstruction because the combinations of SNPs exert synergistic effects on protein function. Even synonymous polymorphisms within haplotypes can have functional consequences that are drastic

• Vitamin B12 br Conflict of interest statement br Acknowledge

  2021-05-20

  

  Conflict of interest statement Acknowledgements Introduction Spending their last days on earth having already lost many cognitive functions remains a major fear of elderly people. Although during the last century their lifespans increased, the so-called “old-age diseases” became more and mo

• We observed the IVM potentiation

  2021-05-20

  

  We observed the IVM potentiation of currents induced by the EC5 of Glu or GABA and the IVM inhibition of currents induced by the EC90 of Glu or GABA in wild-type GluCls and GABACls. The EC50 of IVM for the potentiation in GluCls was 3.5-fold smaller than that in GABACls (Fig. 4, Fig. 8B, Table 2), a

• br Materials and methods br Results and discussion br Conclu

  2021-05-20

  

  Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta

• Although in vitro and in

  2021-05-20

  

  Although, in vitro and in vivo immunosuppressive effects of female steroids have been described in fish (Yamaguchi et al., 2001, Law et al., 2001), their mode of action was not evaluated in detail. Consequently, it is of considerable interest to investigate the intracellular pathways that regulate t

• ERR is present early in the developing

  2021-05-20

  

  ERRβ is present early in the developing placenta in a subset of hesperetin in extra-embryonic ectoderm destined to make up the chorion.19, 20 ERRβ is likely essential for reproduction. ERRβ expression is essential for the maintenance of pluripotency and self-renewal potential in mouse embryonic stem

• br Protein protein interactions of LEI

  2021-05-20

  

  Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino TKI-258 receptor substitution in the RSL can led to the inhibition of a totally different pro

• The Lysine mutant is located in the tail region of

  2021-05-20

  

  The Lysine429 mutant is located in the tail region of 5-HT2A, which is predicted to be unstructured. This region has been shown to interact, in vitro, with PSD95 and leads to differences in signaling (Xia et al., 2003). The ASK motif, a component of the tail region, is also important for regulation

• br Experiments and Methods br Results and Discussion br Conc

  2021-05-20

  

  Experiments and Methods Results and Discussion Conclusions Here, the interactions between two newly-synthesized carbazole derivative—cationic δ,δ′‑diazacarbazoles and DNA were characterized by several spectroscopic means, including UV–Vis and fluorescence, AFM and fluorescence imaging. The

• ASC was reported as a potent antiviral and

  2021-05-20

  

  ASC was reported as a potent antiviral and antifungal agent, and its derivatives could modulate a variety of physiological activities, such as anti-tumor, anti-metastatic, and anti-diabetic activities in animals. Mie Tsuruga et al. found that 4-o-methylascochlorin had immunosuppressive activity, but

• Investigations of mice lacking up

  2021-05-19

  

  Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other xylometazoline australia regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13. Mouse models a

• Inopportunely normal aging brings about decreases in frontal

  2021-05-19

  

  Inopportunely, normal aging brings about decreases in frontal D1 receptor densities and a gradual decline in postsynaptic markers of dopamine in striatal, neocortical, and limbic areas of the Methicillin sodium salt (Bäckman et al., 2006, de Keyser et al., 1990, Karrer et al., 2017, Suhara et al.,

• On the one hand levels of up

  2021-05-19

  

  On the one hand, levels of up to 20 nM P4 have been reported for a cyprinid species, Labeo rohita, in summer (Suresh et al., 2008). Similarly, P4 concentrations in tilapia, Oreochromis mossambicus, were found to range up to 27 nM (Cornish, 1998). Nevertheless in sturgeon P4 levels of approximately 3

• In this study we investigated whether the Ednra signaling

  2021-05-19

  

  In this study, we investigated whether the Ednra signaling is involved in Hoxa9/Meis1-mediated leukemogenesis. We found an upregulation of Ednra in leukemic murine bone marrow (BM) ubiquitin conjugating enzyme overexpressing Hoxa9 and Meis1 compared to cells overexpressing Hoxa9 alone. We showed th

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