• The role of Epac in the regulation of intracellular

  2020-10-21

  

  The role of Epac in the regulation of intracellular Ca homeostasis and contractility is still matter of debate. In rat adult cardiomyocytes, acute Epac stimulation decreased the amplitude of Ca transients [6], [9], [10] with either no changes [6] or increments [9] in cell shortening, suggesting an e

• br Roles of DDR in epithelial cell

  2020-10-20

  

  Roles of DDR1 in epithelial cell differentiation Roles of DDR1 in cell migration, and invasion Dichotomous functions of DDR1 in disease progression Conclusions and perspectives The switch in XCT790 from DDR1 to DDR2 during EMT is another important issue. The DDRs may exert distinct or r

• br Experimental Procedures br Author Contributions br Acknow

  2020-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Research in the Davis laboratory was supported by grants 4R37NS019904, 5R01NS052351, and 1R35NS097224 from NINDS. Research in the Martemyanov laboratory was supported by grants DA036596 and DA026405 from NIDA, and MH105482 from NI

• Introduction Nucleic acids are polyanionic and their negativ

  2020-10-20

  

  Introduction Nucleic acids are polyanionic and their negatively charged nucleotides allow the binding of cationic dyes, such as acridine orange (3,6-dimethylaminoacridine). Acridine orange (AO) was first synthesized in 1889, but its ability to bind nucleic acids was only reported in 1940, with grea

• Regarding their reported beneficial properties on the digest

  2020-10-20

  

  Regarding their reported beneficial properties on the digestive tract, the aim of this study was to evaluate the effect of water extracts of three Hypericum sps., HP, HA, HU and some of the main phenolic compounds (Ch, R and Q) on DNA protection against oxidative and alkylating DNA damage induced by

• Compound was synthesized by the directed metallation procedu

  2020-10-20

  

  Compound () was synthesized by the directed -metallation procedure (DOM) at the stage of the amide using butyl lithium and dry ice as CO source for the introduction of the carboxylic group. Thiophene amides were prepared from commercial 3-thiophenecarboxylic 2-NBDG by conversion into the acid chlori

• Significantly less is known about regulation of

  2020-10-20

  

  Significantly less is known about regulation of phytocystatin gene expression. A genomic clone corresponding to the barley cystatin Icy gene has been characterized (Gaddour et al., 2001) and the function of its promoter region has been analysed by Martínez et al. (2005b). Bioinformatic analysis of t

• br Study br Study meta analyses br Discussion

  2020-10-20

  

  Study 1 Study 2: meta-analyses Discussion Ten studies have examined the associations of 5-HTTLPR and COMT Val158Met with alexithymia. However, the findings were mixed. In this study, we found that neither the 5-HTTLPR nor COMT Val158Met is associated with alexithymia. The previous findings

• Endothelin appears to have direct effects on neoplastic cell

  2020-10-20

  

  Endothelin 1 appears to have direct effects on neoplastic Lonidamine by inducing cellular proliferation, angiogenesis, migration, invasion, and inhibition of apoptosis [10]. Endothelin 1 mediates mitogenic effects in some epithelial tumors such as colorectal, ovarian, and prostate cancers [11], [12

• Dipeptidyl peptidase inhibitors DPP is or gliptins stimulate

  2020-10-20

  

  Dipeptidyl peptidase-4 inhibitors (DPP-4is or gliptins) stimulate both post-meal insulin secretion and inhibit mibefradil secretion in a glucose-dependent manner, rendering the risk of hypoglycaemia minimal [10]. They are weight-neutral or may even induce slight weight loss. Their good efficacy has

• Notochord is a transient structure differentiating at early

  2020-10-19

  

  Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated monensin receptor surrounded by a unique ECM structure improperly called notochordal BM. As in chicken and a

• br Other pathways involved in

  2020-10-19

  

  Other pathways involved in the preventive and therapeutic potential of flavonoids in neurodegenerative diseases Rather than the induction of MAPK/ERK pathway, flavonoids actively modulate other critical intracellular neuronal survival and death protein kinases pathways, more importantly PI3K/Akt,

• br Materials and methods br Results br

  2020-10-19

  

  Materials and methods Results Discussion Inflammatory signalling and in particular the arachidonic Florfenicol cascade have been suggested as targets for disease modification, optimization of the therapeutic response, and even restoration of pharmacosensitivity (Potschka, 2010). Recently, w

• ACA Multiple technologies exist for analyzing the contents

  2020-10-19

  

  Multiple technologies exist for analyzing the contents of single cells, including single-cell DNA sequencing, RNA expression analysis, and protein level and activity measurements (Hu et al., 2018; Narrandes & Xu, 2018; Ortega et al., 2017; Wang & Navin, 2015). Single-cell DNA sequencing is generally

• ACE also known as Kininase II

  2020-10-19

  

  ACE also known as Kininase II is an important enzyme of the Renin angiotensin AMI5 inhibitor system (RAAS) (Novo et al., 1987), it is believed to be a potent blood pressure regulator and also plays a crucial role in activation of the bradykinin receptor via inactivation of bradykinin which works to

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