• The process of ubiquitination is a

  2020-08-05

  

  The process of ubiquitination is a multi-step process ultimately leading to the covalent modification of a protein substrate with small molecule ubiquitin. There are three types of ubiquitination: 1) mono-ubiquitination in which single ubiquitin is attached to target 2) multi ubiquitination or poly-

• br The PQQ and heme b

  2020-08-05

  

  The PQQ and heme b cofactors of CcPDH are located in the 45 kDa AA12 and the 21 kDa AA8-cytochrome domains, respectively, and these domains are connected by a proline-rich linker region. The domain organization of CcPDH resembles those of some CDHs, which have a flavin-containing AA3 domain instea

• br The PQQ and heme b

  2020-08-05

  

  The PQQ and heme b cofactors of CcPDH are located in the 45 kDa AA12 and the 21 kDa AA8-cytochrome domains, respectively, and these domains are connected by a proline-rich linker region. The domain organization of CcPDH resembles those of some CDHs, which have a flavin-containing AA3 domain instea

• The molecular formula of was determined

  2020-08-05

  

  The molecular formula of 3 was determined to be C20H19NO8 (12 degrees of unsaturation) deduced from its positive HRESIMS at m/z 402.1182 [M+H]+ (calcd for 402.1183), 13C NMR and DEPT spectra. The 1H NMR spectrum of 3 (Table 1) reveals the presence of two methyl [δH 2.16 (s, H-10); δH 1.88 (s, H-10′)

• Colony stimulating factor receptor CSF R or cFMS is a

  2020-08-05

  

  Colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It is activated by binding with CSF-1 and IL-34, which stimulates differentiation, proliferation, survival and migration of monocyte-macrophage lineage cells., , , Also, macrophages produce inflammatory me

• Previously published results on this

  2020-08-05

  

  Previously published results on this topic are inconsistent. Stressin1-A, a novel CRF1 receptor agonist, increased anxiety-like behavior in the social interaction and shock-probe tests [51]. Pharmacological blockade of CRF1 (NBI-30775) reversed both CRF-induced increases in startle and CRF-induced d

• Introduction Ubiquitylation is a post translational modifica

  2020-08-04

  

  Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dysfunctions. Single ubiquiti

• The identification of a gatekeeper

  2020-08-04

  

  The identification of a gatekeeper COG 133 sale also suggests that alternative DDR2 inhibitors may be required to overcome acquired resistance. Additional DDR2 inhibitors that have been isolated include the recently identified alkaloid natural products discoipyrroles A-D and the chemotherapeutic Ac

• As there were no significant differences of cholesterol lowe

  2020-08-04

  

  As there were no significant differences of cholesterol-lowering efficacy among the three BBR doses, a lower dose than 50mg/kg·d might be equally effective. Thus, a dose optimization study should be conducted prior to clinical application. According to the dose translation from animals to humans [46

• Inasmuch as hepatocytes are initially refractory to

  2020-08-04

  

  Inasmuch as hepatocytes are initially refractory to the enzyme inducing effects of CYP450 inducers, cultures must be maintained for at least 36–48 h before treatment with test articles and/or known CYP450 inducers, at which time the hepatocytes are expressing liver-specific genes and a near-normal m

• Structure similarity searches were conducted using the

  2020-08-04

  

  Structure similarity searches were conducted using the standalone version of the DALI program with the query structures scanned against a local current version of the PDB that has all chains as separate entries (Holm and Sander, 1995). The structural hits for each query were collected, even if the D

• A strong support for a dual role

  2020-08-04

  

  A strong support for a dual role of microglia may be due to distinct microglial phenotypes, which have been broadly categorized into M1 (classically activated, pro-inflammatory) and M2 (alternatively activated, anti-inflammatory) (Martinez and Gordon, 2014, Franco and Fernandez-Suarez, 2015, Kawabor

• Anhydrotetracycline hydrochloride br Materials and methods b

  2020-08-03

  

  Materials and methods Results Discussion Consistent with previous reports (Barr et al., 2010, Vuong et al., 2010), the current study demonstrates that rats treated with amphetamine exhibit heightened anxiety states during withdrawal. Furthermore, icv. infusion of a CRF2 receptor antagonist

• 360A The FPGA software development is fully automated

  2020-08-03

  

  The FPGA software development is fully automated by FPGA logic synthesis tools and commercial EDAs of FPGA vendors. After programming an RTL (Register-Transfer Level) design with HDLs, the design is transformed into a gate-level design (i.e., netlist) by synthesis software such as ‘Synopsys Synplify

• br Conflict of interest statement br Introduction Cardiovasc

  2020-08-03

  

  Conflict of interest statement Introduction Cardiovascular diseases (CVDs) are the leading cause of death in the world. Data from WHO showed that an estimated 17.5 million people died from CVDs in 2012. Cardiac hypertrophy, primarily characterized by increased cardiomyocyte size, is considered

15394 records 753/1027 page Previous Next First page 上5页 751752753754755 下5页 Last page