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As the main effector of nuclear cytoplasmic transport in cel
2018-10-30
As the main effector of nuclear-cytoplasmic transport in cells, XPO1 also exports cargos such as tumor suppressor and growth regulatory proteins. Deregulation of the XPO1-mediated nuclear export can result in uncontrolled cell growth and carcinogenesis (Kau et al., 2004; Turner and Sullivan, 2008) a
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Andexanet alpha is a modified recombinant FXa
2018-10-30
Andexanet alpha is a modified recombinant FXa lacking enzymatic activity which is currently in an earlier stage of development for neutralisation of direct and indirect FXa inhibitors. A phase 3 study to evaluate the effect of andexanet in bleeding patients receiving FXa-inhibitors started in 2015.
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buy SAR-302503 br Materials Methods br Results br Discussion
2018-10-30
Materials & Methods Results Discussion We have used a partial DNA2 protein structure based on the homology between the helicase domain of DNA2 and yeast Upf1–RNA U15 complex and human Upf1–ADP complex (Chakrabarti et al., 2011; Cheng et al., 2007) to identify 3 well defined pockets (Sites 1
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The US Department of Agriculture USDA and
2018-10-30
The US Department of Agriculture (USDA) and US Department of Health and Human Services recommend 2 cups (3–4 servings (U.S. Department of Health and Human Services and U.S. Department of Agriculture, 2000)) of Avasimibe per day for active women. One cup of fruit (U.S. Department of Health and Human
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HOBt Supplier Regions of linkage disequilibrium LD were
2018-10-30
Regions of linkage disequilibrium (LD) were defined for the three loci tagged by SNPs reaching genome-wide significance. rs17599026, associated with urinary frequency, tags a 106kb region of LD (base position 137,657,783–137,763,798; Fig. 2A) containing part of KDM3B (including the promoter region t
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Viral diseases due to Monodon Baculovirus MBV and Hepatopanc
2018-10-29
Viral diseases due to Monodon Baculovirus (MBV) and Hepatopancreas Parvovirus (HPV) in hatchery reared larvae have been reported in India [6,36,24]. Although MBV is relatively well tolerated by P. monodon[5] it has been implicated in mass mortalities in shrimp cultured at high densities [10]. Infect
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br Materials and methods br
2018-10-29
Materials and methods Brief discussion Indicative peptide stereochemistries are shown in Fig. 1. In the absence of second shell O atoms, the native peptide, 3GSO_P, is under-coordinated in respect to the reference (also see Fig. 3b) and may not be differentiated from the other peptides exhibit
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br Experimental design materials and methods br
2018-10-29
Experimental design, materials and methods Acknowledgments The authors would like to acknowledge the generous support of Dr. Elena Hidalgo (Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain) for kindly providing the yeast strain, Dr. Ranjan K. Nandy (Di
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The ANOVA test carried out on the data set for
2018-10-29
The ANOVA test carried out on the data set for all sites and the result was displayed in Tables 4–6. The results showed significant differences in the means for solar Tipifarnib received quarterly at the stations independently. The results revealed that for Port Harcourt, significant differences li
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The of this study was to test the hypothesis that
2018-10-29
The of this study was to test the mitomycin that self-administered and interviewer-administered methods may yield different results. The research team also hypothesized that privacy of the interview and the gender of interviewer may have an important interaction with this association, supporting t
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Ideally ascertainment of participants in population based
2018-10-29
Ideally, ascertainment of participants in population-based studies should be free of selection biases, thus creating conditions for generating data representative of the general population – “a representative brain” (Falk et al., 2013). As we pointed out elsewhere, previous imaging cohorts used diff
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No study has investigated the
2018-10-29
No study has investigated the neural correlates of pro-social preferences in young infants. However, a few studies have demonstrated that the infant ERP component P400 is related to processing of goal directed actions such as grasping (Bakker et al., in press) and pointing (Gredebäck et al., 2010; M
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So how exactly are growth mindsets linked with resilience
2018-10-29
So how exactly are growth mindsets linked with resilience to setbacks? Research has primarily focused on the associations between mindsets and motivational variables such as attributions and achievement goals to address this question (Dweck et al., 1995; Dweck and Leggett, 1988; Hong et al., 1999; M
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The present study is the first to investigate
2018-10-29
The present study is the first to investigate whether increased cerebral blood flow (CBF) in the hippocampus is associated with aerobic fitness during childhood. This hypothesis cannot be directly tested with traditional BOLD techniques, given that BOLD can change depending on a number of factors re
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As for the acantholysis the patient had
2018-10-29
As for the acantholysis, the patient had negative direct immunofluorescence and indirect immunofluorescence studies, which exclude autoimmune bullous diseases. In addition to keratinocyte injury induced shedding, exfoliative toxin A produced by targets desmoglein 1 and may cause acantholysis. Moreo
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